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Literature summary extracted from

  • Francis, S.E.; Banerjee, R.; Goldberg, D.E.
    Biosynthesis and maturation of the malaria aspartic hemoglobinases plasmepsins I and II (1997), J. Biol. Chem., 272, 14961-14968.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.23.38 membrane proplasmepsin I is a type II integral membrane protein that is transported though the secretory pathway before cleavage to the soluble form Plasmodium falciparum 16020
-
3.4.23.38 vacuole
-
 Plasmodium falciparum 5773
-
3.4.23.39 membrane proplasmepsin II is a type II integral membrane protein that is transported though the secretory pathway before cleavage to the soluble form Plasmodium falciparum 16020
-
3.4.23.39 vacuole
-
 Plasmodium falciparum 5773
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.38 additional information Plasmodium falciparum plasmepsin I is synthesized and processed to the mature form soon after the parasite invades the red blood cell ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.38 Plasmodium falciparum
-
-
-
3.4.23.39 Plasmodium falciparum
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.23.38 proteolytic modification proplasmepsin maturation appears to require acidic conditions, proplasmepsin maturation may not be autocatalytic in vivo Plasmodium falciparum
3.4.23.39 proteolytic modification proplasmepsin maturation appears to require acidic conditions, proplasmepsin maturation may not be autocatalytic in vivo Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.38 additional information plasmepsin I is synthesized and processed to the mature form soon after the parasite invades the red blood cell Plasmodium falciparum ?
-
 ?